Laboratory tests on the engineering properties of sensor-enabled geobelts (SEGB)

To measure geosynthetic reinforcement strains, sensor-enabled geobelts (SEGB) that perform the reinforcement and self-measurement functions were developed in this paper. The SEGB of high-density polyethylene (HDPE) filled with carbon black (CB) were fabricated by both the industry and the laboratory. To study the mechanical properties and tensoresistivity performance of the SEGB, in-isolation tests and in-soil tests were performed. Hot pyrocondensation pipes (HPP) were used to protect the SEGB against the influence of water. For the SEGB specimens developed in the laboratory, the optimal CB filler content was 47.5%. For the SEGB fabricated by the industry, the optimal CB content was slightly decreased compared to the SEGB fabricated in the laboratory. For the modified SEGB sealed with HPP, the strain at the fracture was improved, while its tensile stress and the frictional property of the geobelt-soil interfaces both decreased slightly. In the pull-out tests, the self-measurement function of the SEGB was proved to be effective for evaluating the deformation behavior of geosynthetic reinforcement. The results are helpful for further application of SEGB technology in engineering.     

pH-sensitive self-assembling property of poly(ethyleneimine)/cinnamic acid mixture and its effect on pH-dependent release of monoolein cubic phase

Poly(ethyleneimine) (PEI)/cinnamic acid (CA) mixture was self-assembled into microsphere in aqueous phase. As the pH value increased, the self-assembly became hardly formed. As the molar ratio of the amino group of PEI to the carboxyl group of CA increased, the pH window for the formation of self-assembly became broader. The phase transition temperature of cubic phase was 58.5–67.5°C, depending on the PEI/CA content. The release of dye loaded in cubic phase containing PEI/CA increased in a first-order fashion. The release degree was higher at a lower pH value.     

Simulation Study on Hydrogen-Heating-Power Poly-Generation System based on Solar Driven Supercritical Water Biomass Gasification with Compressed Gas Products as an Energy Storage System

Supercritical water gasification driven by solar energy is a promising way for clean utilization of biomass with high moisture content, but direct discharge of liquid residual causes energy waste and decreases energy efficiency. To reduce energy waste, a poly-generation system for hydrogen-rich gas production coupling heat supply and power generation based on supercritical water gasification of biomass driven by concentrated solar energy was established in this paper, which also provided a novel energy storage method to overcome the shortcomings of solar discontinuity. Thermodynamic model of the system was proposed and life cycle assessment(LCA) of the system was conducted. Influence of different parameters(temperature of 600℃ to 800℃, outlet temperature of heat exchanger of 42℃ to 56℃, biomass slurry concentration of 5% to 6.5%) on the gasification performance, energy and exergy efficiency, energy distribution and global warming potential(GWP) was discussed. The results indicated that hydrogen yield increased as gasification temperature increased since free radical reaction was enhanced which gas production reaction was classified into. Molar fraction of hydrogen increased as gasification temperature increased and reached 65.6% at 750℃. Energy and exergy efficiency of the system reached 74.84% and 34.87% at 700℃ and 600℃ respectively and that of gas production was 18.15% at 650℃, which was the highest. Increasing reaction temperature and decreasing biomass slurry concentration were effective ways to decrease GWP. Optimal operating parameter was reaction temperature of 650℃, outlet temperature of heat exchanger of 50℃ and biomass concentration of 5%.     

基于信息熵—集对分析的煤矿隐患排查治理风险评估模型

以煤矿安全隐患排查治理风险为研究对象，分析隐患排查闭环管理全过程，并基于此建立了隐患排查治理能力纵向评估指标体系，融合熵值法和集对分析理论，建立了煤矿安全隐患排查治理风险纵向评估模型，为企业更好地了解自身隐患排查治理能力及变化发展趋势提供参考，最后进行了实例分析。     

多功能橡胶硫化活性剂ZH-73对全钢载重子午线轮胎胎面胶性能的影响

研究多功能橡胶硫化活性剂ZH-73对子午线轮胎胎面胶硫化特性、加工性能、物理性能和动态力学性能等的影响。结果表明:加入2份硫化活性剂ZH-73,混炼胶的门尼焦烧时间略缩短,t90延长,流动性提高,加工性能改善;硫化胶老化前后物理性能相当,60℃的损耗因子明显减小;成品轮胎耐久性能提高,滚动阻力系数降低。     

花椒风味油的制取及品质研究

以花椒果皮为原料,采用大豆油热浸法制取花椒风味油。以花椒风味油的酸价、过氧化值和感官评分为考察指标,通过单因素实验和正交实验优化制取工艺条件。采用顶空固相微萃取-气相色谱-质谱联用技术对花椒风味油和大豆油中挥发性风味成分进行测定。结果表明:制取花椒风味油的最佳工艺条件为浸提温度95℃、浸提时间20 min、花椒果皮添加量15%,在此条件下制取的花椒风味油香气浓郁、麻味足、色泽好且感官评分最高,其酸价(KOH)为0. 40 mg/g,过氧化值为5. 07 mmol/kg,感官评分为9. 1。花椒风味油中维生素E总量为1 869. 86 mg/kg,远高于大豆油中的742. 07 mg/kg;甾醇含量相较于大豆油几乎不变;脂肪酸组成与大豆油的基本相同;花椒风味油中共鉴定出9类83种挥发性风味成分,大豆油中共鉴定出8类25种挥发性风味成分,花椒风味油中挥发性风味成分主要是烯烃类和醇类(相对含量86. 99%),大豆油中主要是烯烃类和醛类(相对含量87. 26%);花椒风味油中醇类18种,占总量的40. 97%,大豆油中醇类仅1种,占总量的1. 74%;花椒风味油中醛类物质含量仅为1. 91%,而大豆油中醛类物质含量为12. 69%。     

Development of Core-Shell Nanoparticle Drug Delivery Systems Based on Biomimetic Mineralization

Among various drug-delivery systems, core-shell nanoparticles have many advantages. Inspired by nature, biomimetic synthesis has emerged as a new strategy for making core-shell nanoparticles in recent years. Biomimetic mineralization is the process by which living organisms produce minerals based on biomolecule templating that leads to the formation of hierarchically structured organic–inorganic materials. In this minireview, we mainly focus on the synthesis of core-shell nanoparticle drug-delivery systems by biomimetic mineralization. We review various biomimetic mineralization methods for fabricating core-shell nanoparticles including silica-based, calcium-based and other nanoparticles, and their applications in drug delivery. We also summarize strategies for drug loading in the biomolecule-mineralized core-shell NPs. Current challenges and future directions are also discussed.     

Detecting Cysteine in Bioimaging with a Near-Infrared Probe Based on a Novel Fluorescence Quenching Mechanism

Near-infrared (NIR) fluorescent probes are very significant for detecting cysteine in biological systems. Herein, we report a highly selective and sensitive NIR turn-on fluorescent probe (BDP-NIR) based on BODIPY with large Stokes shift (105 nm) for detecting Cys. We clarified the sensing mechanism based on the different thiol-induced S_NAr substitution/rearrangement reaction of the probe with cysteine and homocysteine/glutathione, which leads to the corresponding amino- and thiol-BODIPY dyes with distinct photophysical properties. Moreover, a novel mechanism of fluorescence quenching was demonstrated by density functional theory calculation. The reason for the fluorescence quenching of the probe might be intersystem crossing (from singlet to triplet excited state). Moreover, BDP-NIR had a high linear dynamic range of 0–500 μM, which was promising for detecting cysteine quantificationally. Significantly, BDP-NIR was capable of sensing endogenous cysteine in living cells and in vivo.     

基于TRIZ理论滤咀排列鼓工装夹具优化设计

针对滤咀排列鼓工装夹具所存在的制造难度大,精度难于保证,效率低的问题。利用TRIZ理论进行分析,根据技术矛盾解决方法并结合问题的实际情况,获得了具体可行的解决方案。经过实践证明,此设计方案是可行的、可靠的,大大缩短了夹具的加工周期,提高了生产效率,节约了成本。     

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation.